parenteral dosage form
solutions that are more than skin deep
Bioresorbable polymers have been commercialized for more than 50 years, however, until now, no manufacturer has offered a single source of three key excipients used to formulate these revolutionary drug delivery systems that are designed to improve patients’ lives.
With the addition of Viatel™ bioresorbable polymers, Ashland provides a comprehensive line of products for parenteral, controlled release drug delivery. Complementary excipients include Aqualon™ CMC PH BET sodium carboxymethyl cellulose, a suspending agent for two-component systems; and Pharmasolve™ n-methyl-2-pyrrolidone, a versatile solubilizer for one-component systems.
Parenteral formulations present unique challenges to formulators. Ashland has products that can help address these challenges.
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Cavitron™ and CAVASOL* HPBCD and HPGCD
The molecular structure of cyclodextrins creates a bucket-like cavity that can function to complex with molecules or functional groups on molecules. The substitution of hydroxyl groups on native cyclodextrins to make hydroxypropyl-ß- or hydroxypropyl-γ-cyclodextrins (HPBCD or HBGCD) significantly enhances their solubility and makes them more suitable for drug solubilization. This mechanism makes the Cavitron and CAVASOL HPBCDs and HPGCDs capable ...
Plasdone™ povidone C grades
Ashland offers a comprehensive range of Plasdone povidones (PVP). Plasdone povidones are a family of water-soluble polymers based on N-vinylpyrrolidone that combine a unique set of properties for application in a wide variety of dosage forms. Plasdone povidones are commonly used as binders for the development of tablet formulations, whether manufactured by wet granulation, dry granulation or direct compression. Plasdone K polymers are used in sol...
Pharmasolve™ N-methyl-2-pyrrolidone (NMP) is a versatile solubilizer for one-component systems. It is a water-miscible polar aprotic solvent with high interfacial activity. Pharmasolve™ NMP is manufactured in a facility with ISO 9001:2015 and EXCiPACT GMP certifications. It is used as a drug solubilizer and penetration enhancer in human and animal parenteral dosage forms.
Viatel™ bioresorbable polymers
Ashland offers five families of bioresorbable polymers for parenteral controlled-release drug delivery systems and medical devices. For drug delivery, Ashland offers amorphous homopolymers and copolymers, including: Poly(D,L-lactide) (PDLLA) and Poly(D,L-lactide-co-glycolide) (PLGA). For medical devices, Ashland offers semi-crystalline and amorphous homopolymers and copolymers including: Poly(L-lactide) (PLLA), Poly(ɛ-caprolactone) (PCL) and P...
Aqualon™ CMC PH BET sodium carboxymethyl cellulose
Aqualon™ sodium carboxymethylcellulose (CMC) is made by reacting sodium monochloroacetate with alkalicellulose under rigidly controlled conditions. The resultant anionic polymer is purified and dried. Purified CMC for personal care and cosmetic applications is typically sold at 99.5 percent minimum purity. In addition to thickening aqueous systems, CMC is used in personal care products for water binding, syneresis control and its ability to suspe...